Man Boobs and Peptic Ulcer Therapy

Man boobs has been often linked as a side effect of cimetidine (Tagamet) and has been sometimes normally linked with omeprazole (Prilosec) treatment. Another usual ulcer cure, ranitidine (Zantac), has also been linked with man boobs in a particular case report.

To guess the possibility of man boobs with a variety of drugs used for the cure of peptic ulcer, a British research group revealed these after studying men who received these type of prescriptions from their general physicians for more than a four-year period. Over 81,000 men received as a minimum one prescription for cimetidine, misoprostol, omeprazole or ranitidine. Men were disqualified from the study who had a past record of man boobs, testicular cancer, breast cancer, liver disease, or androgen treatment.

All through the case study, man boobs developed in 153 men. The greater part almost 84% of cases were self-reported by patients, and in 43 % of patients, man boobs was one-sided. In 46 % of patients, the circumstance moved back, and in an extra 18 %, incomplete drop taken place.

The researchers estimated that the possibility of man boobs was to a large extent improved with cimetidine use however not with the additional three drugs. The period of maximum threat was between the 7th and 12th month of cimetidine cure and was subjective by every day dosage. The maximum danger taken place with dosages of over 1,000 mg on a daily basis. Patients who pursued this type of treatment were estimated to have a 40-fold threat, compared with patients who did not consumed cimetidine.

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Causes and Threats of Man Boobs

The causes of man boobs are numerous. A hunt for a common reason has not been victorious. A lot of researchers accept as true that in a range of cases, a changed androgen/estrogen ratio causes changes in cellular components in breast tissue. This could be because of:

• Reduction in making of androgen
• Boost in estrogen development
• Reduction in sensitivity of breast tissue to androgens

A few drugs can also encourage breast growth. They act together with the usual levels of testosterone and estrogen, and disturb the balance in various manners. Man boobs is a common result of estrogen dealing in patients suffering from prostate cancer. Drugs that may cause man boobs consists of:

• Hormones like androgens, anabolic steroids, estrogen agonists
• Antiandrogens or androgen-synthesis inhibitors
• Antibiotics like isoniazid, ketoconazole, metronidazole
• Anti-ulcer medications like cimetidine
• Cancer chemotherapeutics, mainly alkylating agents
• Cardiovascular drugs, like captopril and digitoxin
• Psychoactive agents, like diazepam and tricyclic antidepressants
• Recreational drugs, like alcohol and marijuana
• Penicillamine


Alcohol and drugs can cause man boobs by taking off estrogen and invigorating androgen making. Steroids and other surplus androgens are from time to time transformed by the body into estrogens and as a result cause male breast troubles.

To turn around the breast enlargement, it may be achievable to alter medications.

Men of more than 50 years age have a tendency to manufacture smaller amount of androgens like testosterone or put on fat tissue that changes androgen into estrogen. In 3-5% of reported cases, man boobs can indicate lung, liver, or adrenal cancer. Tumors can produce estrogen, disturbing the hormonal balance.

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